British Columbia ostrich farmers ordered to cull a herd of 400 due to an avian flu outbreak are holding onto hope that the Canadian Food Inspection Agency will change its mind before their kill date in just over two weeks.

The federal agency sent Universal Ostrich Farms Inc. a notice on Dec. 31 instructing their ostriches to be destroyed and disposed of by Feb. 1, but the owners are asking for more time to prove their farm should be spared.

They鈥檙e making the case that the flightless birds 鈥� which are part of an ongoing international research project on COVID-19 antibodies 鈥� can instead be used to study the mechanics of the avian flu that infected the youngest members of their herd.

Of their 400 ostriches, about 10 per cent have died since avian flu hit their property in Edgewood, approximately 200 kilometres east of Kelowna, said Katie Pasitney, who is the daughter of farm co-owner Karen Espersen. She said the flu spread after a flock of wild ducks landed nearby.

Some of the ostriches on their farm are over 30 years old, but it鈥檚 the very young ones that mainly seem to be affected by the virus, Pasitney said.

鈥淲e would be culling 300 plus absolutely healthy animals,鈥� Pasitney said.

Pasitney said the CFIA only tested two ostriches that died at the beginning of the outbreak in December. They have asked for more testing to be done, and are considering bringing in third party testing.

Espersen has been in the ostrich business since 1991. Three years ago they stopped selling meat, pivoted to conduct scientific research on the animals and founded a bioscience company to commercialize ostrich antibodies.

Since then the ostriches have been the subject of a research project in collaboration with Dr. Yasuhiro Tsukamoto, president of Kyoto Prefectural University in Japan, also known as Dr. Ostrich. He鈥檚 been extracting COVID-19 antibodies from ostrich eggs in B.C., building on his decades of research on the antibodies in ostrich egg yolk that can block infectious diseases.

Tsukamoto said his research can be applied to avian flu.

鈥淐urrently, I have a stockpile of ostrich-derived neutralizing antibodies against H5N1 in Japan, primarily intended for use in masks. However, due to their exceptionally high neutralizing activity, these antibodies can also be applied to livestock,鈥� Tsukamoto said in an email.

In a statement to The Canadian Press, the CFIA said the World Organization for Animal Health classifies ostriches as poultry, and that 鈥淗umane depopulation and disposal is required for all poultry premises infected with highly pathogenic avian influenza.鈥�

On. Jan. 10, the CFIA denied the farm鈥檚 application for an exemption path which exists for select flocks that demonstrate 鈥渟ignificant genetic value to the industry.鈥�

Flocks that don鈥檛 meet the criteria of rare and valuable genetics are ordered to depopulate, the agency said.

鈥淲e do not take these decisions lightly and consider the best science in our decisions. However, once an order to destroy animals is issued, it is final.鈥�

But Pasitney said they just need more time to show the value of these animals.

She said the ostriches are on a strict quarantine protocol, pose no flight risk, and live in a remote area that鈥檚 not in the vicinity of commercial poultry farms, with the closest city an hour and a half away. She said the only people who interact with the animals are the farm co-owners, and that they disinfect the ostriches鈥� feeding dishes, step into foot baths at every barn entrance and sanitize the truck used to feed animals, which is no longer driven into town.

An Alberta Health Services board member, who became aware of the B.C. farm ten years ago when it started looking into studying the ostriches鈥� immune systems, said the CFIA could monitor the day-to-day operations of the farm if that鈥檚 of concern.

鈥淵ou鈥檝e got an opportunity. You鈥檝e got a flock that was infected by ducks. You鈥檝e got a flock where you know, I think the last number I heard is that 75 or 85 per cent of them are surviving. Maybe you should take a look at this and ask yourselves why are they surviving? This is a very important health item,鈥� Dr. Lyle Oberg said.

Oberg had written to the CFIA in support of the farm.

Dr. Scott Weese, an infectious disease veterinarian professor at the University of Guelph, said culling is used as an 鈥渆nd tool鈥� to stop potential transmission.

鈥淎nd it will definitely do that. The question is, do we need to do that? Are there alternatives that can be done that can achieve the same thing?鈥�

He said this is where there are nuances that need to be considered, such as if the spread is containable and if culling will eradicate the disease.

In this case, Weese said avian flu is already widespread in Canada.

According to CFIA surveillance posted online, there are 3,459 positive wildlife cases in the country, and about 66 premises with infected domestic birds.

鈥淲e鈥檙e not eradicating H5N1 by culling these ostriches because it鈥檚 all over the place. And we鈥檙e probably not going to drop the broader risk overall very much because there鈥檚 so much out there,鈥� Weese said.

Weese, who has not visited the farm, said broadly that such decisions come down to evaluating the risk in the grand scheme. Infection control inspectors are going to err on the side of eliminating risk while farmers will want to save animals, he said.

鈥淭hat鈥檚 where you get into different perspectives driving different approaches鈥� Weese said.

鈥淵ou鈥檝e got to find that sweet spot in the middle.鈥�